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Start a clinic / Mississippi

How to start a medical clinic in Mississippi.

What a founder needs to know in Mississippi: who can own a practice, which state approvals apply, how nurse practitioners and PAs can work, and where to register. Every fact links to its source.

Updated October 2026Sources linked
MSMississippiStarting a clinic, at a glance
Corporate practice of medicine
LimitedFew restrictions, with conditions
Certificate of need program
YesState review for some facilities or equipment
Nurse practitioner authority
Reduced practiceAANP classification
Register your business with
Mississippi Secretary of State, Business Services
Checked October 2026

Ownership: The Mississippi State Board of Medical Licensure's Corporate Practice of Medicine policy (3.02) says the Board does not regulate the form of a physician's business arrangement as long as the physician keeps control of clinical judgment (and of billing and fees where possible), takes no referral payments, complies with anti-kickback law, preserves patient choice, and approves advertising; shareholders of a professional corporation must be licensed physicians.

Certificate of need: MSDH runs a CON program that covers new health care facilities, capital expenditures over the thresholds, newly offered ambulatory surgical services, MRI, PET and cardiac catheterization, and acquisition of major medical equipment (2026 threshold $3 million).

Nurse practitioners: AANP classifies Mississippi as reduced practice; NPs must practice within a board-approved collaborative relationship with a Mississippi-licensed physician or dentist (Miss.

Who can own a medical clinic in Mississippi

The Mississippi State Board of Medical Licensure's Corporate Practice of Medicine policy (3.02) says the Board does not regulate the form of a physician's business arrangement as long as the physician keeps control of clinical judgment (and of billing and fees where possible), takes no referral payments, complies with anti-kickback law, preserves patient choice, and approves advertising; shareholders of a professional corporation must be licensed physicians. Physician employment by other entities is therefore possible, while PCs and PLLCs remain the usual physician-owned structures.

Sources: msbml.ms.gov

Business entity and registration

Physicians commonly form a professional corporation (shareholders must be licensed physicians per Board policy) or a professional LLC, registered with the Mississippi Secretary of State through its business filings portal.

Sources: msbml.ms.gov, sos.ms.gov

Certificate of need in Mississippi

MSDH runs a CON program that covers new health care facilities, capital expenditures over the thresholds, newly offered ambulatory surgical services, MRI, PET and cardiac catheterization, and acquisition of major medical equipment (2026 threshold $3 million). Private physician offices are excluded from the health care facility and ambulatory surgical facility definitions, but a physician practice that starts MRI, PET or ambulatory surgery services, or buys major medical equipment, can still need CON.

Sources: msdh.ms.gov, msdh.ms.gov, ncsl.org

Licenses, registrations and state agencies

The MSDH Division of Health Facilities Licensure and Certification licenses hospitals, nursing homes, hospices, home health agencies, personal care homes and other specialized facilities; private physician offices are excluded from the CON definitions of health care facility and ambulatory surgical facility. We did not confirm the ASC license category on the licensure page itself.

Sources: msdh.ms.gov, msdh.ms.gov

Mississippi-specific requirements to know

The Board's prescribing rules (Part 2640, Chapter 1) include a separate rule on pain management medical practices (Rule 1.14), rules on chronic pain prescribing, and a Board registration for a controlled substances certificate (Rule 1.3). The Mississippi PMP is run through the Board of Pharmacy (pmp.mbp.ms.gov). Starting MRI, PET or ambulatory surgery services triggers CON review even inside a physician practice.

Sources: msbml.ms.gov, msbml.ms.gov, mbp.ms.gov, msdh.ms.gov

Agencies you will deal with

Nurse practitioners and physician assistants

Nurse practitioners: AANP classifies Mississippi as reduced practice; NPs must practice within a board-approved collaborative relationship with a Mississippi-licensed physician or dentist (Miss. Code Ann. 73-15-20).

Sources: storage.aanp.org

Physician assistants: Mississippi PAs practice under continuous supervision by a Board-approved physician who practices in-state at least 20 hours a week, with 120 days or 960 hours of on-site supervision for new graduates, a 75-mile practice limit unless the Board approves a protocol, monthly chart review and quarterly meetings (MSBML Part 2615, Rule 1.6).

Sources: msbml.ms.gov

Med spas, injectables and IV therapy in Mississippi

A joint Medical Licensure and Nursing Board policy (3.15) lets a nurse practitioner administer Botox only if the NP is documented as educated and competent, the collaborating physician is trained in Botox, the NP's protocol covers it, and the physician examines the patient and documents approval. Board policy 3.12 requires direct supervision of medical assistants, generally meaning the physician is in the clinic whenever the assistant provides care. The Board also has a separate administrative rule on laser devices (Part 2635, Chapter 3) whose text we could not extract.

Sources: msbml.ms.gov, msbml.ms.gov

Planning an aesthetic or IV business? See how to start a med spa and how to start an IV therapy business.

Step-by-step checklist in Mississippi

  1. Choose your structure and check ownership rules. Decide who will own the practice and confirm it fits Mississippi’s corporate practice of medicine rules. The Mississippi State Board of Medical Licensure's Corporate Practice of Medicine policy (3.02) says the Board does not regulate the form of a physician's business arrangement as long as the physician keeps control of clinical judgment (and of billing and fees where possible), takes no referral payments, complies with anti-kickback law, preserves patient choice, and approves advertising; shareholders of a professional corporation must be licensed physicians.
  2. Form the entity with the Mississippi Secretary of State, Business Services. Physicians commonly form a professional corporation (shareholders must be licensed physicians per Board policy) or a professional LLC, registered with the Mississippi Secretary of State through its business filings portal.
  3. Get federal numbers. Apply for an EIN from the IRS, then a Type 2 NPI for the practice and Type 1 NPIs for each clinician through NPPES.
  4. Confirm licenses with the Mississippi State Board of Medical Licensure. Every physician needs a Mississippi license. Check the board’s rules for any practice registrations, supervision agreements or office requirements before opening.
  5. Check certificate of need and facility licensing. MSDH runs a CON program that covers new health care facilities, capital expenditures over the thresholds, newly offered ambulatory surgical services, MRI, PET and cardiac catheterization, and acquisition of major medical equipment (2026 threshold $3 million).
  6. Register to prescribe. Register with the DEA for controlled substances and complete any Mississippi controlled substance registration and prescription monitoring program enrollment. The Board's prescribing rules (Part 2640, Chapter 1) include a separate rule on pain management medical practices (Rule 1.14), rules on chronic pain prescribing, and a Board registration for a controlled substances certificate (Rule 1.3).
  7. Set up lab, safety and privacy basics. Get a CLIA certificate if you will run any lab tests, including waived tests, and put HIPAA privacy and security and OSHA policies in place.
  8. Enroll with Medicare, Medicaid and insurers. Enroll in Medicare through PECOS, enroll with Mississippi Division of Medicaid (fiscal agent Gainwell Technologies) and start commercial credentialing early, because payer enrollment often takes months.
  9. Plan staffing around NP and PA rules. AANP classifies Mississippi as reduced practice; NPs must practice within a board-approved collaborative relationship with a Mississippi-licensed physician or dentist (Miss. Code Ann. 73-15-20).
  10. Launch your marketing before opening day. Claim your Google Business Profile, publish a website with online booking and start ads and content four to eight weeks before you open, so the schedule is not empty on day one.

The national steps are explained in more detail in our guide to how to start a medical clinic, and costs are broken down in how much it costs to start a clinic.

Marketing a new clinic in Mississippi

New clinics usually fail on cash flow before they fail on care. The fastest fix is patients booked before opening day: a complete Google Business Profile, a website with online booking, local search ads and a few weeks of social content showing the team and the space. We run that launch for new clinics and keep it going once the doors open.

Plan your Mississippi launch with us →

Important. This guide is general information checked against official and professional sources in October 2026. It is not legal advice. Rules change and details depend on your services, so confirm your plan with a healthcare attorney licensed in Mississippi and with the agencies listed above.

Sources

  1. https://www.msbml.ms.gov/board-policies
  2. https://www.sos.ms.gov/business-services
  3. https://msdh.ms.gov/page/resources/21948.pdf
  4. https://msdh.ms.gov/page/30,0,84.html
  5. https://www.ncsl.org/health/certificate-of-need-state-laws
  6. https://storage.aanp.org/www/documents/no-index/state-fact-sheets/mississippi.pdf
  7. https://www.msbml.ms.gov/mississippi-administrative-code
  8. https://msdh.ms.gov/page/30,0,83.html
  9. https://www.msbml.ms.gov/sites/default/files/2026%20Law%20Documents/MSBML_Administrative_Code_Title30.pdf
  10. https://www.msbml.ms.gov/rules_laws_policies
  11. https://www.mbp.ms.gov/

Nearby state guides

LouisianaArkansasTennesseeAlabamaAll states
Mississippi questions

Starting a clinic in Mississippi, answered.

Can a non-physician own a medical clinic in Mississippi?
The Mississippi State Board of Medical Licensure's Corporate Practice of Medicine policy (3.02) says the Board does not regulate the form of a physician's business arrangement as long as the physician keeps control of clinical judgment (and of billing and fees where possible), takes no referral payments, complies with anti-kickback law, preserves patient choice, and approves advertising; shareholders of a professional corporation must be licensed physicians. Physician employment by other entities is therefore possible, while PCs and PLLCs remain the usual physician-owned structures.
Does Mississippi require a certificate of need to open a clinic?
MSDH runs a CON program that covers new health care facilities, capital expenditures over the thresholds, newly offered ambulatory surgical services, MRI, PET and cardiac catheterization, and acquisition of major medical equipment (2026 threshold $3 million). Private physician offices are excluded from the health care facility and ambulatory surgical facility definitions, but a physician practice that starts MRI, PET or ambulatory surgery services, or buys major medical equipment, can still need CON.
Can nurse practitioners open their own practice in Mississippi?
AANP classifies Mississippi as reduced practice; NPs must practice within a board-approved collaborative relationship with a Mississippi-licensed physician or dentist (Miss. Code Ann. 73-15-20).
Who can perform Botox, laser or IV therapy in Mississippi?
A joint Medical Licensure and Nursing Board policy (3.15) lets a nurse practitioner administer Botox only if the NP is documented as educated and competent, the collaborating physician is trained in Botox, the NP's protocol covers it, and the physician examines the patient and documents approval. Board policy 3.12 requires direct supervision of medical assistants, generally meaning the physician is in the clinic whenever the assistant provides care. The Board also has a separate administrative rule on laser devices (Part 2635, Chapter 3) whose text we could not extract.
Where do I register a medical practice in Mississippi?
Physicians commonly form a professional corporation (shareholders must be licensed physicians per Board policy) or a professional LLC, registered with the Mississippi Secretary of State through its business filings portal.